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Future Blog Post

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Blog Post number 1

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Mapping general anesthesia states based on electro-encephalogram transition phases

Published in NeuroImage, 2024

In human patients, overdosing during general anesthesia can lead to cognitive impairment. Cortical electro-encephalograms are used to measure the depth of anesthesia. They allow for correction, but not prevention, of overdose. However, data-driven approaches open new possibilities to predict the depth of anesthesia. We established an electro-encephalogram signal-processing pipeline, and constructed a predictive map representing an ensemble of gradual sedation states during general anesthesia in mice. In particular, we identified crucial electro-encephalogram patterns which anticipate signs of overdose several minutes before they occur. Our results bring a novel paradigm to the medical community, allowing for the development of individually tailored and predictive anesthetic regimens.

Recommended citation: Loison, V., et al. "Mapping general anesthesia states based on electro-encephalogram transition phases." Neuroimage 285 (2024).
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UNHaP: Unmixing Noise from Hawkes Process to Model Learned Physiological Events

Published in ICML AI4Science Workshop, 2024

Physiological signal analysis often involves identifying events crucial to understand the underlying biological dynamics. Traditional methods rely on handcrafted procedures or supervised learning, presenting challenges such as expert dependence, lack of robustness, and the need for extensive labeled data. Data-driven methods like Convolutional Dictionary Learning (CDL) offer an alternative but tend to produce spurious detections. This work introduces UNHaP (Unmix Noise from Hawkes Processes), a novel approach addressing the joint learning of temporal structures in events and the removal of spurious detections. Leveraging marked Hawkes processes, UNHaP distinguishes between events of interest and spurious ones. By treating the event detection output as a mixture of structured and unstructured events, UNHaP efficiently unmixes these processes and estimates Hawkes process parameters. This approach significantly enhances the understanding of event distributions while minimizing false detection rates.

Recommended citation: Staerman, G., Loison, V., & Moreau, T. (2024). Unmixing Noise from Hawkes Process to Model Learned Physiological Events. arXiv preprint arXiv:2406.16938.
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